Author(s):
Ruchita Bachhav, Shivraj Jadhav, Yash Sunil Bachhav
Email(s):
shiva.007ind@gmail.com
DOI:
10.52711/2231-5713.2026.00053 
Address:
Ruchita Bachhav1, Shivraj Jadhav2*, Yash Sunil Bachhav2
1Department of Pharmaceutics, Divine College of Pharmacy, Satana, (Affiliated to Savitribai Phule Pune University, Pune), Maharashtra, India, 423301.
2Department of Pharmaceutics, Mahatma Gandhi Vidyamandir’s Samajshri Prashantdada Hiray College of Pharmacy, Malegaon (Affiliated to Savitribai Phule Pune University, Pune), Maharashtra, India, 423203.
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2026
ABSTRACT:
Mood disorders such as depression, bipolar disorder, and anxiety are closely linked to imbalances in key neurotransmitters including dopamine, serotonin, glutamate, norepinephrine, and GABA. Excessive accumulation of these neurotransmitters can result in excitotoxicity, neuroinflammation, and behavioural dysregulation, ultimately impairing mental health. Traditional pharmacological approaches often lack specificity, cause systemic side effects, or fail to maintain neurotransmitter homeostasis. In recent years, nanosponges—nanoscale, porous, and biocompatible polymeric structures have emerged as promising tools for targeted detoxification of excess neurotransmitters. This review explores the mechanisms by which nanosponges adsorb and regulate neurotransmitter levels, focusing on surface functionalization, passive adsorption, blood-brain barrier (BBB) permeability, and stimuli responsive release. Animal models have demonstrated the efficacy of nanosponges in adsorbing or detoxifying excess neurotransmitters, effectively modulating dopaminergic and GABAnergic systems in preclinical settings. Overall, nanosponges represent a safe strategy for restoring neurotransmitter balance and stabilizing mood, with immense potential in the treatment of neuropsychiatric disorders.
Cite this article:
Ruchita Bachhav, Shivraj Jadhav, Yash Sunil Bachhav. A Review on Nanosponges for Neurotransmitter Detoxification. Asian Journal of Pharmacy and Technology. 2026; 16(4):381-8. doi: 10.52711/2231-5713.2026.00053
Cite(Electronic):
Ruchita Bachhav, Shivraj Jadhav, Yash Sunil Bachhav. A Review on Nanosponges for Neurotransmitter Detoxification. Asian Journal of Pharmacy and Technology. 2026; 16(4):381-8. doi: 10.52711/2231-5713.2026.00053 Available on: https://www.ajptonline.com/AbstractView.aspx?PID=2026-16-4-8
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