Explore Expecting Mechanism of actions of Albizzia lebbeck for its Pharmacological actions

Devendra S. Shirode; Shrutika S. Gotipamul

doi:10.52711/2231-5713.2026.00043

Asian Journal of Pharmacy and Technology

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2231-5713 (Online)
2231-5705 (Print)

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Explore Expecting Mechanism of actions of Albizzia lebbeck for its Pharmacological actions

Author(s): Devendra S. Shirode, Shrutika S. Gotipamul

Email(s): shrutigotipamul28@gmail.com

DOI: 10.52711/2231-5713.2026.00043

Address: Devendra S. Shirode, Shrutika S. Gotipamul
Department of Pharmacology, Dr. D. Y. Patil College of Pharmacy, Akurdi, Pune - 411044, Maharashtra, India.
Affiliated to Savitribai Phule Pune University, Pune, Maharashtra, India.
*Corresponding Author

Published In: Volume - 16, Issue - 3, Year - 2026

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ABSTRACT:
Albizzia lebbeck (Siris) a multipurpose medicinal plant has been used in traditional medicine for various purposes, widely used in Ayurvedic medicine, demonstrates diverse pharmacological actions attributed to its rich phytoconstituents such as flavonoids, saponins, alkaloids, glycosides, sterols, fatty acids, terpenoids, proteins and minerals. The plant exhibits a wide range of pharmacological activities including, antimicrobial, anti-inflammatory, anti-diabetic, antimicrobial, antioxidant, antidiarrheal, anxiolytic, nootropic, antifertility, actions activities. These compounds may contribute to the plant's pharmacological effects through various mechanisms. This article highlights the mechanism of actions of activities like Anti-inflammatory activity due to extracts may inhibit pro-inflammatory enzymes (e.g., COX, LOX) and cytokines (e.g., TNF-a, IL-1ß), reducing inflammation; Antioxidant activity due to plant's flavonoids, phenolic compounds, and saponins may scavenge free radicals, reducing oxidative stress; Antimicrobial activity by disrupt microbial cell membranes, inhibit enzyme activity, or interfere with DNA replication; Anti-diabetic activity by inhibiting a-amylase, a-glucosidase, or enhance insulin sensitivity, regulating blood glucose levels. The importance of Albizzia lebbeck herb lies in its extensive traditional use for treating respiratory, gastrointestinal, neurological, and inflammatory disorders, validated by modern pharmacological studies. The plant’s broad spectrum of activities and safety profile make it a valuable resource for drug discovery and development, supporting both traditional healing systems and contemporary therapeutic needs.

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Cite this article:
Devendra S. Shirode, Shrutika S. Gotipamul. Explore Expecting Mechanism of actions of Albizzia lebbeck for its Pharmacological actions. Asian Journal of Pharmacy and Technology. 2026; 16(3):307-6. doi: 10.52711/2231-5713.2026.00043

Cite(Electronic):
Devendra S. Shirode, Shrutika S. Gotipamul. Explore Expecting Mechanism of actions of Albizzia lebbeck for its Pharmacological actions. Asian Journal of Pharmacy and Technology. 2026; 16(3):307-6. doi: 10.52711/2231-5713.2026.00043 Available on: https://www.ajptonline.com/AbstractView.aspx?PID=2026-16-3-13

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