Author(s):
Avani N. Doshi, Vidhi Kotadiya, Isha R. Mishra
Email(s):
avanidoshi20211@gmail.com
DOI:
10.52711/2231-5713.2026.00048 
Address:
Avani N. Doshi1*, Vidhi Kotadiya2, Isha R. Mishra3
1HOD & Professor of Pharmaceutical QA/Chemistry, K. B. Raval College of Pharmacy, Gandhinagar, Gujarat, India. ORCIDs: 0000-0002-9959-2039
2Associate Professor of Pharmaceutical QA/Chemistry K. B. Raval College of Pharmacy, Gandhinagar, Gujarat, India. ORCIDs: 0009-0005-5098-3433
3Research Scholar, K. B. Raval College of Pharmacy, Gandhinagar, Gujarat, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2026
ABSTRACT:
A simple, rapid, economical, precise, and accurate stability-indicating RP-HPLC method for estimating ticagrelor and Aspirin in a synthetic mixture has been developed. A reverse phase high-performance liquid chromatographic method was developed for the estimation of Ticagrelor and Aspirin in a synthetic mixture has been developed. The separation was achieved using Waters Symmetry C18 (150mm × 4.6mm × 5µ), Phosphate buffer (pH 7.5) and methanol as mobile phase, at a flow rate of 1.0ml/min. Detection was carried out at 215nm, and retention times of Ticagrelor and Aspirin were found to be 3.853 and 6.829min. The method has been validated for linearity, accuracy, and precision. Linearity observed for Ticagrelor and Aspirin 45 – 135 µg/ml. The developed method was found to be accurate, precise, and rapid for estimating ticagrelor and Aspirin in a synthetic mixture. The drug was subjected to stress conditions of hydrolysis, oxidation, photolysis, and Thermal degradation under the same chromatographic conditions. The stress samples were assayed on RP-HPLC system.
Cite this article:
Avani N. Doshi, Vidhi Kotadiya, Isha R. Mishra. The Research Article on Stability Indicating RP-HPLC Method Development and Validation for Simultaneous Estimation of Ticagrelor and Aspirin in Synthetic Mixture. Asian Journal of Pharmacy and Technology. 2026; 16(4):344-0. doi: 10.52711/2231-5713.2026.00048
Cite(Electronic):
Avani N. Doshi, Vidhi Kotadiya, Isha R. Mishra. The Research Article on Stability Indicating RP-HPLC Method Development and Validation for Simultaneous Estimation of Ticagrelor and Aspirin in Synthetic Mixture. Asian Journal of Pharmacy and Technology. 2026; 16(4):344-0. doi: 10.52711/2231-5713.2026.00048 Available on: https://www.ajptonline.com/AbstractView.aspx?PID=2026-16-4-3
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