Formulation and Evaluation of Orodispersible Tablets of Naproxen Sodium and Ondansetron HCl for Migraine: A Review

Raj Nandani; Arti Kori; Shivanand Patil

doi:10.52711/2231-5713.2026.00055

Asian Journal of Pharmacy and Technology

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2231-5713 (Online)
2231-5705 (Print)

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Formulation and Evaluation of Orodispersible Tablets of Naproxen Sodium and Ondansetron HCl for Migraine: A Review

Author(s): Raj Nandani, Arti Kori, Shivanand Patil

Email(s): Email ID Not Available

DOI: 10.52711/2231-5713.2026.00055

Address: Raj Nandani, Arti Kori, Shivanand Patil
Shree Dev Bhoomi Institute of Education Sciences and Technology, Dehradun, Uttrakhand, India.
*Corresponding Author

Published In: Volume - 16, Issue - 4, Year - 2026

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ABSTRACT:
Migraine is a chronic neurological disorder characterized by recurrent episodes of severe headache associated with nausea, vomiting, photophobia, and phonophobia. Conventional oral dosage forms often fail to provide rapid therapeutic relief because delayed gastric emptying during migraine attacks reduces drug absorption. Orodispersible tablets (ODTs) rapidly disintegrate in the oral cavity without the need for water, providing faster drug release, improved bioavailability, and better patient compliance. The present review discusses the formulation and evaluation of ODTs containing Naproxen Sodium and Ondansetron HCl for migraine management. Naproxen Sodium provides analgesic and anti-inflammatory action, whereas Ondansetron HCl effectively controls nausea and vomiting. Their combination in an ODT offers rapid symptom relief, enhanced therapeutic efficacy, and improved patient convenience. The review also highlights formulation approaches, evaluation parameters, advantages, limitations, recent technological developments, and future prospects of ODTs in migraine therapy. Overall, ODTs represent an effective and patient-friendly drug delivery system for improving migraine treatment outcomes.

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Cite this article:
Raj Nandani, Arti Kori, Shivanand Patil. Formulation and Evaluation of Orodispersible Tablets of Naproxen Sodium and Ondansetron HCl for Migraine: A Review . Asian Journal of Pharmacy and Technology. 2026; 16(4):395-1. doi: 10.52711/2231-5713.2026.00055

Cite(Electronic):
Raj Nandani, Arti Kori, Shivanand Patil. Formulation and Evaluation of Orodispersible Tablets of Naproxen Sodium and Ondansetron HCl for Migraine: A Review . Asian Journal of Pharmacy and Technology. 2026; 16(4):395-1. doi: 10.52711/2231-5713.2026.00055 Available on: https://www.ajptonline.com/AbstractView.aspx?PID=2026-16-4-10

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DOI: 10.5958/2231–5713