Author(s):
Janani Priya M K, Sowmiyaa P, Venkateswaramurthy N
Email(s):
nvmurthi@gmail.com
DOI:
10.52711/2231-5713.2026.00057 
Address:
Janani Priya M K, Sowmiyaa P, Venkateswaramurthy N*
Department of Pharmacy Practice, J.K.K. Nattraja College of Pharmacy, Kumarapalayam - 638183, Namakkal District, Tamil Nadu, India.
*Corresponding Author
Published In:
Volume - 16,
Issue - 4,
Year - 2026
ABSTRACT:
Skeletal muscle injuries remain a major clinical challenge, with current treatment options often yielding suboptimal functional recovery. While the intrinsic regenerative capacity of muscle tissue has been extensively characterized over the past two decades, translating this knowledge into effective pharmacological interventions has proven difficult. This review critically examines the current landscape of drug-based approaches for enhancing muscle regeneration, synthesizing evidence from preclinical models and early clinical trials. We analyse the mechanistic rationale and therapeutic potential of several drug classes, including anti-inflammatory agents, growth factors, anabolic compounds, and emerging small molecules. Notably, the literature reveals significant heterogeneity in study designs, outcome measures, and reported efficacy, making direct comparisons challenging. The timing of pharmacological intervention emerges as a critical determinant of therapeutic success, with growing evidence suggesting that both excessive suppression and prolonged inflammation impair regenerative outcomes. We identify key knowledge gaps, including the need for standardized preclinical models, better understanding of dose-response relationships, and long-term safety data. Despite these challenges, several promising candidates warrant further investigation in well-designed clinical trials. A more nuanced understanding of the complex interplay between inflammation, regeneration, and fibrosis will be essential for developing targeted therapies that optimize functional muscle recovery.
Cite this article:
Janani Priya M K, Sowmiyaa P, Venkateswaramurthy N. Pharmacological Strategies for Skeletal Muscle Regeneration: Current Evidence and Future Perspectives. Asian Journal of Pharmacy and Technology. 2026; 16(4):413-0. doi: 10.52711/2231-5713.2026.00057
Cite(Electronic):
Janani Priya M K, Sowmiyaa P, Venkateswaramurthy N. Pharmacological Strategies for Skeletal Muscle Regeneration: Current Evidence and Future Perspectives. Asian Journal of Pharmacy and Technology. 2026; 16(4):413-0. doi: 10.52711/2231-5713.2026.00057 Available on: https://www.ajptonline.com/AbstractView.aspx?PID=2026-16-4-12
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